Barry Halliwell is currently at UCL on sabbatical leave from the National University of Singapore. Barry is without doubt one of the world leaders of the field of free radical biology and he has agreed to give a seminar to be held on May 18th from 1.00-2.00 in the Gavin de Beer lecture theatre (just adjacent to the Anatomy Entrance on Gower street).
The Wanderings of a Free Radical
Professor Barry Halliwell
Senior Advisor to the President, and
Tan Chin Tuan Centennial Professor
National University of Singapore
Oxygen free radicals and related “reactive oxygen species” are fundamental to healthy life; they help drive evolution and the damage that they can do (“oxidative damage”) is involved in most, if not all, human diseases and in the ageing process. The fact that reactive oxygen species cause such harm whilst playing important pathophysiological roles can be explained by Darwinian Medicine. Early work by my group helped elucidate the key roles played by transition metals (especially iron) in oxidative damage as well as the pathway used by plants to remove H2O2 (the ascorbate-glutathione cycle). Plants are key to human life; they supply us with oxygen, they provide a variety of nutrients with antioxidant abilities, and diets rich in plants lower the risk of developing many diseases, including diabetes, atherosclerosis, dementias and stroke. Exactly why is uncertain. The reasons for the usual lack of effectiveness of antioxidants/supplements in decreasing risk of disease or severity of disease in intervention studies will be discussed. One explanation is that antioxidants are often ineffective in decreasing levels of oxidative damage in humans. Antioxidants work better in cell culture and in rodent models (which questions the relevance of some mouse models of human disease, and cell culture studies can generate many artefacts). So how then can we minimize oxidative damage in the human body? Strategies will be discussed. Studies on lifespan and healthspan using C.elegans as a model will also be presented.
References:
Halliwell B and Gutteridge JMC. (2015) Free Radicals in Biology and Medicine. Clarendon Press, Oxford (fifth edition), UK
Biography
Professor Barry Halliwell is Tan Chin Tuan Centennial Professor at the National University of Singapore. An internationally-acclaimed biochemist, Professor Halliwell is known for his seminal work on the role of free radicals and antioxidants in biological systems. The Thomson Reuters lists Professor Halliwell as one of the world’s most highly-cited researchers in Neurobiology & Behaviour, Pharmacology & Toxicology, Biology and Biochemistry. His Hirsch Index is 145. His book Free Radicals in Biology and Medicine is regarded as the authoritative text in the field with its fifth edition published last year.
His research focuses on the role of free radicals and antioxidants in human disease, particularly Alzheimer disease and other brain disorders, such as strokes, and in the ageing process. His interest in identifying important antioxidants in the human diet and in developing novel antioxidants has critical bearing on treating human diseases and understanding how diet might cause or prevent them.
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