Mitochondrial Calcium Signalling
December 8th, 1pm
UCL, Department of Cell and Developmental Biology, Anatomy Building, Gavin De Beer LT
Host: Gyorgy Szabadkai
Gyorgy had a pioneering role in identifying the role of MICU1 in regulating mitochondrial Ca2+ uptake, see:
His previous ‘Greatest Hits’ listed in the Scientist
- Visualized mitochondrial energy production and ion metabolism in single live cells.
- Characterized the behavior of IP3 receptors in cells and described how they produce calcium spikes.
- Demonstrated that calcium spikes stimulate ATP production in mitochondria, and identified the molecular mechanism by which this occurs.
- Discovered a physical tether between mitochondria and the endoplasmic reticulum and described its role in signaling.
- Determined how mitochondrial movements are controlled inside a cell.
- Used real-time, live-cell imaging to observe transient mitochondrial fusion events—aka “kiss and run.”