Mitochondria: balancing health and disease. June 14, 2016


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Chaired by Gyorgy Szabadkai and Michael Duchen (University College of London, UK)

Venue
Kennedy Lecture Theatre, Institute of Child Health, London, UK 
Date
June 14, 2016

Program

08:30 – 09:20 Registration and coffee

09:20 – 09:30 Opening statement

Session 1 Chair: Gyorgy Szabadkai

Opening guest lecture:

09:30 – 10:15 Ian Holt (The Francis Crick Institute, UK): Mitochondrial DNA replication: In search of lost RNA

10:15 – 10:45 Jorge Oliveira (University of Porto, Portugal): Mitochondrial dynamics and autophagy as therapeutic targets in Huntington’s disease

10:45 – 11:15 Marija Sajic (University College London, UK): In vivo imaging of mitochondria in PNS axons – new insights into the role of mitochondrial dynamics and function in physiology and disease

11:15 – 11:45 Break

11:45 – 11:55 Abcam

Session 2 Chair: Shamima Rahman

11:55 – 12:25 Buzz Baum (University College London, UK): Mitochondria and the evolution of eukaryotic cell division

12:25 – 12:40 Joanna Poulton (University of Oxford, UK): Dysregulated mitophagy and mitochondrial transport in “Dominant Optic Atrophy” due to OPA1 (Optic Atrophy 1) mutations

12:40 – 12:55 Danilo Faccenda (The Royal Veterinary College London, UK): The ATPase inhibitory factor 1 prevents the pro-apoptotic processing of OPA1 via an ATP-driven mechanism of ROS scavenging

12:55 – 13:10 Payam Gammage (MRC Mitochondrial Biology Unit, Cambridge, UK): Towards treatment of mitochondrial DNA disorders with engineered nuclease technologies

13:10 – 14:00 Lunch

Session 3 Chair: Christos Chinopoulos

14:00 – 14:30 Tariq Enver (University College London Cancer Institute, UK): Extrinsic transcriptional noise and cell heterogeneity in stem cells

14:30 – 15:00 Giuseppe Gasparre (University of Bologna, Italy): Mitochondrial DNA mutations in cancer: the oncojanus effect

15:00 – 15:15 Shamima Rahman (Institute of Child Health, London, UK): Signal transducer and activator of transcription 2 (STAT2) deficiency is a novel disorder of mitochondrial fission

15:15 – 15:30 Brent Ryan (University of Oxford, UK): Mitochondrial dysfunction in models of Parkinson’s disease

15:30 – 16:30 Break

Session 4 Chair: Michael Duchen

Closing guest lecture:

16:30 – 17:15 David Rubinsztein (University of Cambridge, UK): Autophagy and other pathways that protect against Neurodegeneration

17:15 – 18:15 Poster session and drinks reception

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