Chaired by Gyorgy Szabadkai and Michael Duchen (University College of London, UK)
- Venue
- Kennedy Lecture Theatre, Institute of Child Health, London, UK
- Date
- June 14, 2016
Program
08:30 – 09:20 Registration and coffee
09:20 – 09:30 Opening statement
Session 1 Chair: Gyorgy Szabadkai
Opening guest lecture:
09:30 – 10:15 Ian Holt (The Francis Crick Institute, UK): Mitochondrial DNA replication: In search of lost RNA
10:15 – 10:45 Jorge Oliveira (University of Porto, Portugal): Mitochondrial dynamics and autophagy as therapeutic targets in Huntington’s disease
10:45 – 11:15 Marija Sajic (University College London, UK): In vivo imaging of mitochondria in PNS axons – new insights into the role of mitochondrial dynamics and function in physiology and disease
11:15 – 11:45 Break
11:45 – 11:55 Abcam
Session 2 Chair: Shamima Rahman
11:55 – 12:25 Buzz Baum (University College London, UK): Mitochondria and the evolution of eukaryotic cell division
12:25 – 12:40 Joanna Poulton (University of Oxford, UK): Dysregulated mitophagy and mitochondrial transport in “Dominant Optic Atrophy” due to OPA1 (Optic Atrophy 1) mutations
12:40 – 12:55 Danilo Faccenda (The Royal Veterinary College London, UK): The ATPase inhibitory factor 1 prevents the pro-apoptotic processing of OPA1 via an ATP-driven mechanism of ROS scavenging
12:55 – 13:10 Payam Gammage (MRC Mitochondrial Biology Unit, Cambridge, UK): Towards treatment of mitochondrial DNA disorders with engineered nuclease technologies
13:10 – 14:00 Lunch
Session 3 Chair: Christos Chinopoulos
14:00 – 14:30 Tariq Enver (University College London Cancer Institute, UK): Extrinsic transcriptional noise and cell heterogeneity in stem cells
14:30 – 15:00 Giuseppe Gasparre (University of Bologna, Italy): Mitochondrial DNA mutations in cancer: the oncojanus effect
15:00 – 15:15 Shamima Rahman (Institute of Child Health, London, UK): Signal transducer and activator of transcription 2 (STAT2) deficiency is a novel disorder of mitochondrial fission
15:15 – 15:30 Brent Ryan (University of Oxford, UK): Mitochondrial dysfunction in models of Parkinson’s disease
15:30 – 16:30 Break
Session 4 Chair: Michael Duchen
Closing guest lecture:
16:30 – 17:15 David Rubinsztein (University of Cambridge, UK): Autophagy and other pathways that protect against Neurodegeneration
17:15 – 18:15 Poster session and drinks reception
