Mitochondria: balancing health and disease. June 14, 2016


Chaired by Gyorgy Szabadkai and Michael Duchen (University College of London, UK)

Kennedy Lecture Theatre, Institute of Child Health, London, UK 
June 14, 2016


08:30 – 09:20 Registration and coffee

09:20 – 09:30 Opening statement

Session 1 Chair: Gyorgy Szabadkai

Opening guest lecture:

09:30 – 10:15 Ian Holt (The Francis Crick Institute, UK): Mitochondrial DNA replication: In search of lost RNA

10:15 – 10:45 Jorge Oliveira (University of Porto, Portugal): Mitochondrial dynamics and autophagy as therapeutic targets in Huntington’s disease

10:45 – 11:15 Marija Sajic (University College London, UK): In vivo imaging of mitochondria in PNS axons – new insights into the role of mitochondrial dynamics and function in physiology and disease

11:15 – 11:45 Break

11:45 – 11:55 Abcam

Session 2 Chair: Shamima Rahman

11:55 – 12:25 Buzz Baum (University College London, UK): Mitochondria and the evolution of eukaryotic cell division

12:25 – 12:40 Joanna Poulton (University of Oxford, UK): Dysregulated mitophagy and mitochondrial transport in “Dominant Optic Atrophy” due to OPA1 (Optic Atrophy 1) mutations

12:40 – 12:55 Danilo Faccenda (The Royal Veterinary College London, UK): The ATPase inhibitory factor 1 prevents the pro-apoptotic processing of OPA1 via an ATP-driven mechanism of ROS scavenging

12:55 – 13:10 Payam Gammage (MRC Mitochondrial Biology Unit, Cambridge, UK): Towards treatment of mitochondrial DNA disorders with engineered nuclease technologies

13:10 – 14:00 Lunch

Session 3 Chair: Christos Chinopoulos

14:00 – 14:30 Tariq Enver (University College London Cancer Institute, UK): Extrinsic transcriptional noise and cell heterogeneity in stem cells

14:30 – 15:00 Giuseppe Gasparre (University of Bologna, Italy): Mitochondrial DNA mutations in cancer: the oncojanus effect

15:00 – 15:15 Shamima Rahman (Institute of Child Health, London, UK): Signal transducer and activator of transcription 2 (STAT2) deficiency is a novel disorder of mitochondrial fission

15:15 – 15:30 Brent Ryan (University of Oxford, UK): Mitochondrial dysfunction in models of Parkinson’s disease

15:30 – 16:30 Break

Session 4 Chair: Michael Duchen

Closing guest lecture:

16:30 – 17:15 David Rubinsztein (University of Cambridge, UK): Autophagy and other pathways that protect against Neurodegeneration

17:15 – 18:15 Poster session and drinks reception