Upcoming CfMR seminars Biochemical Society Series
Barry Halliwell, National University of Singapore:
The Wanderings of a Free Radical
May 18th 1pm @ Gavin de Beer LT
Past seminars with mitochondrial themes
2012
Prof. Mike Ryan, from La Trobe University Melbourne, is giving a talk at UCL on Thursday 31st May 1pm entitled:
Mitochondrial biogenesis: building the generator and breaking up the factory
The talk will cover new complex I assembly factors and assembly and function of CI in mitochondrial disease. Mike will also discuss the discovery of new modulators of mitochondrial fission that regulate Drp1 activity.
Venue: Medical Sciences G46 H O Schild Pharmacology LT
Wednesday 9th May, 5pm
Why do chloroplasts and mitochondria carry DNA?
School of Biological and Chemical Sciences, Queen Mary, University of London
followed by drinks in the Housman Room
Tuesday, March 20th, 1:00 pm
Insulin: an old player with novel pathophysiological action on the heart
Prof. Sergio Lavandero
Cardiology Division, University of Texas, Southwestern Medical Centre, Dallas, USA; Centre for Molecular Studies of the Cell, Faculty of Medicine, Santiago, Chile
The Elias Library and Seminar Room (3rd floor)
The Hatter Cardiovascular Institute
UCL Division of Medicine
67 Chenies Mews
London WC1E 6HX
Enquires: Dr.Mihaela Moody (m.mocanu@ucl.ac.uk)
Thursday March 29 at 1pm
Prof Rosario Rizzuto, Università degli Studi di Padova
Title: The mitochondrial calcium uniporter: molecular identification and physiological investigation
Host: Dr Gyorgy Szabadkai
Venue: JZ Lecture Theatre
Seminar of the MRC Centre for Neuromuscular Diseases
“Mitochondrial diseases: from molecules to treatments”
Dr Patrick Chinnery Department of Neurology, University of Newcastle
6th February 2012
Dr Nick Lane Lunch Hour Lecture: Is complex life a freak accident? 24 January 2012
http://www.ucl.ac.uk/gee/gee-events-publication/201206Jan-2
2011
Monday 21st November, 1.00pm
By: Professor John E. Walker
Director of the Medical Research Council Mitochondrial Biology Unit, Cambridge, UK
“The mitochondrion in health and disease”
Abstract:
Almost all proteins found in mammalian mitochondria are encoded by nuclear genes and are imported into the organelle, but thirteen hydrophobic proteins, all of them components of respiratory enzyme complexes, are encoded in mitochondrial DNA (mtDNA). They are synthesised in the organelle, and, together with some of the nuclear gene products, they are assembled into multi-protein complexes that are involved in oxidative phosphorylation. Therefore, mitochondrial diseases can arise from inherited defects in either genome, or they can be acquired by sporadic mutations during the lifetime of an individual. The first pathological mutations associated with mitochondrial dysfunction were linked to mtDNA, and today over a hundred mutations in mtDNA are known to cause disease (http://www.mitomap.org/). Nuclear DNA mutations that affect replication, maintenance and metabolism of mtDNA also lead to disease. Thus, primary defects in mtDNA are amongst the more common types of genetic disorder, and they occur in about 1 in 5,000 of the population. They present themselves as diverse clinical disorders with a variable age of onset, and new forms of mitochondrial disease continue to be identified. Clinical features resulting from mutant mtDNA include neurological impairment, deafness, blindness, muscle weakness, cardiovascular disease, movement or renal dysfunction and endocrine disorders, notably diabetes. Specific mutations of mtDNA are associated with defined syndromes or diseases. For example, some mutations in subunits of complex I cause maternally inherited blindness, and specific tRNA mutations produce discrete neuromuscular syndromes. Mitochondrial dysfunction is increasingly linked to Parkinson’s disease and Alzheimer’s disease. The lecture will discuss our current understanding of the fundamental processes that underlie these diseases and how the fundamental knowledge might contribute to understanding how they arise and how they might be treated.
Bio
Professor John Walker is Director of the Medical Research Council Mitochondrial Biology Unit in Cambridge, UK. He was awarded the Nobel Prize in Chemistry in 1997 for his studies of how the energy currency of biology, the molecule ATP is synthesised in mitochondria. He is a Fellow of the Royal Society, a Foreign Associate of the National Academy of Sciences USA and a Fellow of Sidney Sussex College, Cambridge.
Tea & coffee available on the balcony from 12.40pm
Venue: Kennedy Lecture Theatre, ICH
All Welcome
UCL Cancer Institute Seminar: Metabolomics and Cancer Therapy
Thursday 6th October at 5pm in the Courtyard Café, Paul O’Gorman Building
Dr Eyal Gottlieb – Beatson Institute for Cancer Research, Glasgow
Title: “Metabolomic approaches for cancer therapy“
As a result of increased bioenergetic demands and the need to grow and proliferate faster, cancer cells have unique metabolic traits compared to normal cells. At the same time, cancer cells are exposed to more extreme conditions of metabolic stress due to the uncontrolled growth of the tumour away from the vascular system that provides oxygen and nutrients to its cells. Therefore, cancer cells have developed defence mechanisms that are selected under conditions of stress and cells that survive this strongly selective environment have a more aggressive phenotype. Dr Gottlieb’s work focuses on targeting these survival mechanisms which may help eliminate cancer growth and specifically induce cancer cell death.
Host: Gyorgy Szabadkai (ucgbgsz@ucl.ac.uk) – please contact Dr Szabadkai if you wish to meet with the speaker
All are welcome. A reception will be held after the seminar.
The GEE Seminar programme for Autumn 2011 has been announched. You can read the full listhere.
30 September, 2011 – Mitochondrial dynamics and cell cycle control: an intimate partnership
Time: 16:00 – 17:00
Speaker Information : Jennifer Lippincott-Schwartz. Host: MRC Laboratory of Molecular Cell Biology
Location: Seminar Room, 2nd Floor, MRC Laboratory for Molecular Cell Biology, Gower Street, London, WC1E 6BT
Contact: http://www.ucl.ac.uk/lmcb/
Thursday 29 September at 1pm
Professor Giles Hardingham, University of Edinburgh
Title: Pro-survival and pro-death molecular events downstream of NMDA receptor activity
Host: Prof Patricia Salinas
Venue: Gavin De Beer Lecture Theatre
Tuesday 22 March at 12.50pm
The Molecular Basis of Mitochondrial Respiratory Chain Complex I deficiency
Dr Shamima Rahman, Clinical and Molecular Genetics Unit, Institute of Child Health
Venue: Room C, 2nd Floor, Institute of Child Health
Thursday February 10 – full day symposium
Mitochondria – from the Fundamental Aspects to Medical Importance
Download the programme
Thursday February 10 at 1pm
CDB PhD Student Seminars
- Caroline Dalton. Title: Changes in mitochondrial distribution and ATP levels during oocyte maturation
- Dr Daniel Wilton. Title: Numbing the Schwann cell
Host: Prof Steve Hunt
Venue: Gavin de Beer Lecture Theatre, Anatomy Building
Thursday February 3 at 4pm
Prof Luca Scorrano, School of Medicine, Université de Genève Switzerland
Title: Size matters! Mitochondrial elongation and the control of autophagy
Host: Dr Gyorgy Szabadkai
Venue: A V Hill Lecture Theatre, Medical Sciences Building
2010
Thursday July 15 at 1pm
Prof. Israel Sekler
Department of Physiology, Ben Gurion University of the Negev, Israel
Title: The molecular identification and physiological roles of the mitochondrial Na/Ca exchanger NCLX
Host: Prof Michael Duchen
Venue: Gavin de Beer Lecture Theatre, Anatomy building
Friday July 9 at 2pm
Dr Koji Okamoto
Associate Professor of Molecular Cell Biology Laboratory of Mitochondrial Dynamics, Graduate School of Frontier Biosciences, Osaka University, Japan
Title: Mitophagy: from phenomenology to molecular mechanisms
Host: Takehiro Yasukawa (WIBR)
Venue: A.V. Hill Lecture Theatre, Medical Sciences Building
For abstract, click here
Tuesday 22 June at 1pm
Prof Atan Gross
Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel
Title: MTCH2/MIMP: a new player in mitochondrial apoptosis
Host: Prof Michael Duchen
Venue: A V Hill Lecture Theatre, Medical Sciences building
Monday June 7 at 1pm
Dr Alessandro Prigione
Molecular Embryology and Aging Group, Max Planck Institute for Molecular Genetics, Berlin
Title: Mitochondrial resetting and metabolic shift upon reprogramming of human fibroblasts to pluripotency
Host: Prof Michael Duchen
Venue: Gavin de Beer Lecture Theatre, Anatomy Building
Tuesday 1st June at 5.30pm
SEMINAR OF THE MRC CENTRE FOR NEUROMUSCULAR DISEASES
Title: Mitochondria as ATP consumers: regulation of mitochondrial structure and function by the endogenous inhibitor protein, ATPIF1
Speaker: Professor Michael Duchen, University College London
Venue: Lecture theatre at 33 Queen Square, Followed by informal drinks
Thursday May 6 at 1pm
Dr Margaret Ashcroft
Metabolism and Experimental Therapeutics, UCL Division of Medicine
Title: Novel regulation of the hypoxia-inducible factor (HIF)- oxygen sensing pathway
Host: Prof Michael Duchen
Venue: Gavin de Beer Lecture Theatre, Anatomy Building
Thursday May 6 at 5pm
UCL Cancer Institute Seminar Series
Professor Sir Salvador Moncada, Wolfson Institute for Biomedical Research
Title: Neurons, mitochondria, astrocytes, glycolysis… what’s the connection with cancer?
Host: Kai Stoeber
Sponsor: Clontech
Venue: Courtyard Café, Paul O’Gorman Building
Seminar Series Poster
NOTE: THIS SEMINAR WAS CANCELLED due to flight restrictions
Thursday April 22, 2010
Prof. Israel Sekler
Department of Physiology, Ben Gurion University of the Negev, Israel
Title: The molecular identification and physiological roles of the mitochondrial Na/Ca exchanger NCLX
Thursday March 25 at 1pm
Dr. Daniele Bano, German Centre for Neurodegenerative Diseases, Bonn
Title: Calcium-mediated cell death in neurodegenerative disorders and aging
Host: Dr Gyorgy Szabadkai
Venue: Gavin de Beer Lecture Theatre, Ground Floor, Anatomy Building, Gower Street (click for map)
Friday March 19 at 4pm
Dr. Zu-Hang Sheng, Head, Synaptic Function Section, NINDS, NIH, USA
Title: Axonal mitochondrial transport and its impact on synaptic function and neurodegeneration
Host: Josef Kittler
Venue: H O Schild Lecture Theatre, Medical Sciences Building
Thursday February 4, 2010 at 1pm
Prof John McCarron
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde
Title: Ca2+ signalling in smooth muscle
Host: Prof Michael Duchen
Venue: Gavin de Beer Lecture Theatre, Ground Floor, Anatomy Building, Gower Street
2009
Thursday December 10, 2009 at 1pm
Prof Wolfgang Graier
Medical University of Graz, Austria
“Molecular basis of different modes of mitochondrial Ca2+ fluxes”
Venue: Gavin de Beer Lecture Theatre, Anatomy Building, Gower Street
Department Cell and Developmental Biology
Host: Prof Michael Duchen
Details
Thursday November 26, 2009 at 1pm
Alexei Tepikin, Department of Physiology, University of Liverpool
“From Ca2+ signalling to bioenergetics and cell damage – tales of good and bad Ca2+”
Venue: Seminar room 106, first floor of the Anatomy Building
Department Cell and Developmental Biology
Host: Prof Michael Duchen
Details
Wednesday November 18, 2009 at 4pm
Anthony Poole, Stockholm, Sweden
‘How likely is it that eukaryotes evolved from an archaeon and a bacterium?’
Venue: Biochemistry Lecture Theatre, Darwin Building
November 6th 2009 at 1pm
GENES, DEVELOPMENT & DISEASE THEME SEMINAR
Speaker: Professor Michael Duchen, UCL Research Dept of Cell & Developmental Biology
Title: “IF1 – an endogenous protein regulator of mitochondrial structure and function”
Venue: Room B, Wellcome Trust Building, ICH
November 5th 2009 at 1pm
Prof Juan Bolanos.
Dept of Biochemistry and Molecular Biology, University of Salamanca, Spain
”Neuronal glucose metabolism and oxidative stress: a question of balance”
Venue: Seminar room 106, first floor of the Anatomy Building
Department Cell and Developmental Biology
Host Prof Michael Duchen (m.duchen@ucl.ac.uk)
Details
October 20th 2009 at 1.15pm
“The new biology of ageing”
Professor Dame Linda Partridge (UCL Genetics, Evolution and Environment).
Part of UCL Lunch Hour Lectures.
Full details here
October 15th 2009 at 1pm
Prof Michael Murphy.
MRC Mitochondrial Biology Unit, University of Cambridge
”Using targeted molecules to gain insights into mitochondrial ROS metabolism”
Venue: Seminar room 106, first floor of the Anatomy Building
Department Cell and Developmental Biology
Host Prof Michael Duchen (m.duchen@ucl.ac.uk)
Details
October 14th 2009, 4pm
Martin Embley, Newcastle, UK
‘Origin and evolution of eukaryotic genomes and organelles’
Venue: Biochemistry Lecture Theatre, Darwin Building
October 6th 2009, 5:30 pm
Topic: Convergent pathways in motor neuron degeneration
Location Lecture theatre at 33 Queen Square
Speaker Dr Kevin Talbot. University of Oxford
Department MRC Centre for Neuromuscular Diseases at the Institute of Neurology
Host Professor Martin Koltzenburg and Professor Dimitri Kullmann
Details z.scott@ion.ucl.ac.uk
September 23rd, 2009
Prof Patrick Maxwell’s inaugural lecture
‘How oxygen turned me on‘
WIBR lecture theatre 1.
June 29th, 2009
Dr. Nick Lane, Honorary Reader, UCL Medical School
University College London
“Chemiosmosis and the Foundations of Complex Life”
Venue: Cruciform Lecture Theatre 2 (WIBR)
June 9th, 2009
Dr Andrew Hall, Research Department of Cell and Developmental Biology, UCL
“The role of mitochondria in the renal Fanconi syndrome”
AV Hill Lecture theatre
June 4th, 2009
Dr Parjam Zolfaghari, Research Department of Cell and developmental Biology, UCL
“Role of uncoupling protein-3 on mitochondrial function in a mouse model of sepsis”
AV Hill Lecture theatre
May 16th, 2009
Dr Jorge Oliveira, University of Porto, Portugal
“Selective neurodegeneration and mitochondrial dysfunction in Huntington’s Disease”
Physiology Seminar Room
with funding support from Carl Zeiss
May 14th, 2009
Dr Roberta Gottlieb, Director, Bioscience Centre, Frederick G Henry Chair in Life Sciences,
San Diego State University.
“Cardioprotection requires taking out the trash”
UCL Hatter Institute for Cardiovascular research
April 22nd, 2009
Jose Manuel Cuezva
Centro de Biologìa Molecular Severo Ochoa, Madrid
“The role of mitochondria in cancer progression”
Venue: UCL Institute of Cancer Research
with funding support from Carl Zeiss
April 7th, 2009
Prof Massimo Zeviani, Division of Molecular Neurogenetics, National Neurological Institute, Milan
“Unconventional disease mechanisms in mitochondrial encephalomyopathies?”
MRC CENTRE FOR NEUROMUSCULAR DISEASES
Lecture theatre at number 33 Queen Square
March 19th, 2009
Prof Michael Duchen, Research Department of Cell and developmental Biology, UCL
Title:”Mitochondria as ATP consumers; the cell biology of the ATPase inhibitor protein, IF1″
AV Hill Lecture theatre
March 4th, 2009
Prof. David Carling, MRC Clinical Sciences Centre, Imperial College London,’
“AMPK and the regulation of energy metabolism”
Biochemistry Lecture Theatre, Darwin Building.
March 2nd, 2009
Dr Greg Brewer
University of Southern Illinois
“Age-related Neurotoxicity Targets Identified in Adult Neuron Cultures”
Physiology seminar room
with funding support from Carl Zeiss
January 22nd, 2009
Prof Anne Stephenson
School of Pharmacy, University of London
Title: “Molecular dissection of mitochondrial trafficking complex
Venue: AV Hill Lecture theatre
2008
August 10th, 2008
Dr Evgeny Pavlov
Department of Physiology and Biophysics, University of Calgary
“Involvement of polyphosphate in calcium – induced mitochondrial permeability transition”
UCL Hatter Institute for Cardiovascular research
Prof Luca Scorrano
Venetian Institute of molecular medicine, Padova
“Mitochondrial dynamics in cell life and death”
Hatter Institute for Cardiovascular research
May 15th, 2008
Dr. Gyorgy Szabadkai, Department of Cell and Developmental Biology, UCL
‘Crosstalk between the endoplasmic reticulum
and mitochondria’
UCL Hatter Institute for Cardiovascular research
January 28th, 2008
Professor Andras Spät, Department of Physiology, Semelweiss University, Budapest.
“Control of mitochondrial Ca2+ uptake”
Physiology seminar room
with funding support from Carl Zeiss
2007
November 11th, 2007
Dr Pedro Echave, LMCB, UCL
“Relationship of Mitochondrial biogenesis to cell growth and division”
MRC Laboratory for Molecular and Cellular Biology
